
| icon | info | RA score |
|---|---|---|
| Worlds Apart Clear Chapter 1 of Story mode | 5points | |
| Another Day at the Office Clear Chapter 2 of Story mode | 5points | |
| Return to the Megavents Clear Chapter 3 of Story mode | 5points | |
| Rendezvous with Fate Clear Chapter 4 of Story mode | 5points | |
| Emergency Care Clear Chapter 5 of Story mode | 5points | |
| Nowhere to Hide Clear Chapter 6 of Story mode | 10points | |
| Life and Death Clear Chapter 7 of Story mode | 10points | |
| In the Hearts of Men Clear Chapter 8 of Story mode | 5points | |
| Escaping the Ishimura Clear Chapter 9 of Story mode | 10points | |
| Secrets and Salvation Clear Chapter 10 of Story mode | 25points | |
| RTFM Find every text and audio log in Chapter 1 of Story mode | 4points | |
| P-Sec Case Files Find every text log in Chapter 2 of Story mode | 3points | |
| Please Observe All Posted Warnings Find every text and audio log in Chapter 3 of Story mode | 4points | |
| Passenger Safety Instructions Find every text, audio, and video log in Chapter 4 of Story mode | 5points | |
| Senior Physician's Notes Find every text and audio log in Chapter 5 of Story mode | 4points | |
| Reader's Digest Find every text and audio log in Chapter 6 of Story mode | 4points | |
| Farmer's Almanac Find every text and audio log in Chapter 7 of Story mode | 4points | |
| Prayers of the Unitologist Find every text and audio log in Chapter 8 of Story mode | 3points | |
| Captain's Log Find every text and audio log in Chapter 9 of Story mode | 4points | |
| A Soldier's Memoir Find every text and audio log in Chapter 10 of Story mode | 2points | |
| Just One Bad Day Clear Chapter 1 of Story mode on Impossible difficulty | 10points | |
| Police Brutality Clear Chapter 2 of Story mode on Impossible difficulty | 10points | |
| Megaventing Your Frustrations Clear Chapter 3 of Story mode on Impossible difficulty | 10points | |
| Strange Encounter Clear Chapter 4 of Story mode on Impossible difficulty | 10points | |
| Okay, Maybe a Little Harm... Clear Chapter 5 of Story mode on Impossible difficulty | 10points | |
| Who Puts a Sewer Level on a Spaceship? Clear Chapter 6 of Story mode on Impossible difficulty | 10points | |
| Death and More Death Clear Chapter 7 of Story mode on Impossible difficulty | 10points | |
| What Darkness Lurks Clear Chapter 8 of Story mode on Impossible difficulty | 10points | |
| Last One Alive, Lock the Door Clear Chapter 9 of Story mode on Impossible difficulty | 10points | |
| Officially Retired Clear Chapter 10 of Story mode on Impossible difficulty | 10points | |
| Let Your Tools Do the Talking Complete Chapter 1 of Story mode using only the Rivet Gun | 5points | |
| Multitasking Kill at least 10 Necromorphs during the final hacking sequence of Chapter 2 of Story mode and finish without any mistakes | 5points | |
| Emergency Patch Seal the hatch in Chapter 3 of Story mode in 20 seconds or less. | 5points | |
| Vision Test: Passed Finish the approach sequence in Chapter 4 of Story mode with over 90% hull remaining | 5points | |
| Let the Dead Rest Clear the morgue in Chapter 5 of Story mode without allowing the Infectors to reanimate any corpses | 5points | |
| Clear the Air Catch the Urchin's tentacles in each vent the first time you approach, don't get grabbed, and finish it off in Chapter 6 of Story mode | 5points | |
| The Bigger They Are Defeat the Brute in Chapter 7 of Story mode without taking any damage | 5points | |
| This End Up Complete the zero-G section of Chapter 8 of Story mode without taking any damage | 5points | |
| Mano a Monstro Destory the Spider in Chapter 9 of Story mode without letting it spawn any Leapers | 5points | |
| Biological Conservation Clear Chapter 10 of Story mode with 70 or fewer kills | 5points | |
| Riveting Fully upgrade the Rivet Gun | 5points | |
| The Isaac Special Fully upgrade the Plasma Cutter | 5points | |
| Dedication and Service Fully upgrade the P-Sec Pistol | 5points | |
| Full Auto Fully upgrade the Pulse Rifle | 5points | |
| Prometheus Fully upgrade the Flamethrower | 5points | |
| Wide Beam Fully upgrade the Line Gun | 5points | |
| Lightning in a Bottle Fully upgrade the Arc Welder | 5points | |
| Force Attuned Fully upgrade the Force Gun | 5points | |
| Supreme Collider Fully upgrade the Contact Beam | 5points | |
| Rip and Tear Fully upgrade the Ripper | 5points | |
| Hot and Ready Kill 5 enemies using only charged Rivet Gun shots without missing | 10points | |
| Measure Twice, Cut Once Sever a limb with 10 Plasma Cutter shots in a row | 10points | |
| Fastest Gun in the West Kill 3 enemies with the P-Sec Pistol within 5 seconds of switching weapons | 10points | |
| All Spray, No Pray Reach better than 80% accuracy with the Pulse Rifle after firing at least 200 shots | 10points | |
| Reach Out and Torch Someone Kill 5 enemies with a constant stream of fire from the Flamethrower | 10points | |
| Limbo Lower Now Sever 5 limbs with a single shot using the Line Gun | 10points | |
| AC/Deceased Kill 3 enemies with a single Arc Welder alternate-fire blast | 10points | |
| When You Stop Being Biology and Start Being Physics Kill 3 enemies with a Force Gun alternate-fire Grenade | 10points | |
| No Such Thing as Overkill Kill 20 enemies with the Contact Beam without switching weapons | 10points | |
| Cut to the Quick Sever 7 limbs with a single Ripper blade | 10points | |
| Mining for Gold Earn more than 251,010 points on Challenge 1: Extraction Site | 10points | |
| Center Stage Earn more than 252,010 points on Challenge 2: Central Plaza | 10points | |
| Fixer-Upper Earn more than 253,010 points on Challenge 3: Maintenance Bay | 10points | |
| Cleaning Crew Earn more than 254,010 points on Challenge 4: Mess Hall | 10points | |
| Surgical Precision Earn more than 255,010 points on Challenge 5: Medical Bay | 10points | |
| Royal Flush Earn more than 256,010 points on Challenge 6: Water Tunnel | 10points | |
| When You're Green, You're Growing Earn more than 257,010 points on Challenge 7: East Grow Chamber | 10points | |
| Riding High Earn more than 258,010 points on Challenge 8: Shuttle Bay 47 | 10points | |
| Enjoy the View Earn more than 259,010 points on Challenge 9: Atrium | 10points | |
| Topsy-Turvy Earn more than 260,010 points on Challenge 10: Life Support Room | 10points | |
| Gearing Up Earn a total of 12 stars in Story mode | 5points | |
| Hale and Hearty Earn a total of 24 stars in Story mode | 10points | |
| Stellar Performance Earn all 50 stars in Story mode | 25points | |
| Conservation of Momentum Dismember an enemy with a thrown object | 1points | |
| And Stay Dead! Reach a kill streak of 50 on any stage | 10points | |
| Embodiment of Perfection Complete any stage with 90% or more Perfect Reloads | 10points | |
| A Slow Death Complete any stage using Stasis at least 5 times with 90% or more Stasis accuracy | 10points |