| icon | info |
|---|---|
 | Platinum Trophy Unlock all trophies |
 | Hell of a Start Finish the game on Normal Mode with any character |
 | Gone To Hell Finish the game on Hard Mode with any character |
 | To Hell And Back Finish the game on Very Hard Mode with any character |
 | Hell Hath No Fury… Finish the game on Dante Must Die Mode with any character |
 | Heaven Can Wait Finish the game on Heaven or Hell Mode with any character |
 | Am I My Brother's Keeper Finish the game on any difficulty as Vergil |
 | Worst Kept Secret Complete a Secret Mission with any character |
 | Left No Stone Unturned Complete all Secret Missions with any Character |
 | To Hell With That Kill 100 enemies during the credits |
 | Blood, Sweat, and Tears Pass 666 levels in Bloody Palace Mode |
 | Blood Donor Pass 5000 levels in Bloody Palace Mode |
 | Bloody Hell Complete Bloody Palace Mode |
 | Devilish Deed Achieve an S Rank on any mission with any character |
 | Hellish Honor Achieve an S Rank on all missions (any difficulty or character) |
 | Man's Best Friend Defeat Cerberus |
 | Pest Control Defeat Gigapede |
 | Double Trouble Defeat Agni and Rudra |
 | Sibling Rivalry Survive an encounter with Vergil |
 | Inside Out Defeat the Heart of Leviathan |
 | Lightning In A Bottle Defeat Nevan |
 | Lights Out Defeat Beowulf |
 | Rough Rider Defeat Geryon |
 | Brotherly Love Fight Vergil a second time and prevail |
 | That's Not Lady-Like Defeat Lady |
 | Step Into The Light Defeat Doppelganger |
 | Asylum Defeat Arkham |
 | Big Spender Purchase all Devil Arm skills with Dante |
 | Who's Laughing Now? Defeat Jester in all of his forms |
 | The Path Less Travelled Clear every mission in Yellow Orb Mode |
 | Trend Setter Reach the highest level in all Styles with Dante |
 | Locked 'n Loaded Reach the highest level for any gun with Dante |
 | Maximize Your Health Max out the Health Bar with Dante |
 | Give 'em Hell Max out the Devil Trigger Gauge with Dante |
