| icon | info | RA score |
|---|---|---|
 | Feverish Foursome Win 4-Player Vs. against 3 7-star CPUs with all Virus Levels set to 15 | 25points |
 | Flashy Finish Clear all 3 flashing viruses in One Player Flash mode with a single combo | 10points |
 | Blighted by the Light Win Multiplayer Flash mode against 3 7-star CPUs on Hard Game and Hi Speed Levels | 25points |
 | Green Clear levels 0 to 5 of Classic mode in one run on Hi Speed with no retries (No Redos from the menu) | 5points |
 | Sick Moves Clear levels 6 to 10 of Classic mode in one run on Hi Speed with no retries (No Redos from the menu) | 10points |
 | Unhealthy Obsession Clear levels 11 to 15 of Classic mode in one run on Hi Speed with no retries (No Redos from the menu) | 10points |
 | Ill-fated Attempt Clear levels 16 to 20 of Classic mode in one run on Hi Speed with no retries (No Redos from menu) | 25points |
 | The Doctor Is Insane Clear levels 0 to 21 of Classic mode in one run on Hi Speed with no retries (No Redos from the menu) | 25points |
 | Of Antidotes and Antiheroes Beat Dr. Mario or Wario in Story mode | 5points |
 | Stay Sharp Beat Spearhead in Story mode | 5points |
 | This Is a Stickup Beat Webber in Story mode | 5points |
 | Keeping the Doctor Away Beat Silky or Appleby in Story mode | 5points |
 | Armed and Dangerous Beat Jellybob or Octo in Story mode | 5points |
 | Frog in Your Float Beat Helio or Lump in Story mode | 5points |
 | Stainless Steel Beat Hammer-Bot or Mad Scienstain in Story mode | 5points |
 | Clown Down Beat Rudy in Story mode | 5points |
 | Test Your Mettle, the Stakes are High Beat Metal Mario or Vampire Wario in Story mode | 25points |
 | Cold Case Clear Story mode on S-Hard in one session | 50points |
 | Crutch Win Team Battle against 2 7-star CPUs with all Virus Levels set to 15 | 10points |
 | Still Not as High as the Hospital Bill Clear Score Attack mode with 50,000 points or more on Hard Game and Hi Speed Levels | 10points |
 | Race for the Cure Clear 100 viruses in Marathon mode on Hard Game and Hi Speed Levels | 10points |
 | Gone in a Flash Beat a 7-star Easy and Low CPU in One Player Flash mode while on Hard Game and Hi Speed Levels | 25points |
 | Medical Malpractice Beat a 7-star CPU in Vs. Computer mode without ever clearing all your viruses | 10points |
 | Have Patients Last 20 minutes in Marathon mode | 25points |
 | Surgical Precision Clear Score Attack mode without ever earning more than 100 points at a time | 10points |
 | Break a Leg Beat a 7-star CPU with both Virus Levels set to 15 and Speed Level on Hi | 25points |
