| icon | info | score |
|---|---|---|
| Another Piece of Cake Beat The Doctor Who Cloned Me campaign on Easy Difficulty | 20 | |
| Let's Rock Out Beat The Doctor Who Cloned Me campaign on Normal Difficulty | 30 | |
| Bloody Red Rover Kill 30 enemies with the moon rover | 10 | |
| Bubble Buster Kill 10 expanded enemies with melee attacks | 10 | |
| Heart to Heart Finish Doctor Proton | 20 | |
| Threesome Kill 3 enemies within 3 seconds with the Impregnader | 10 | |
| Sticky Bomb Like You! Put a Trip Mine on a live alien unlocked Jan 2nd, 2012 9:06 pm | 10 | |
| Party Animal Drink all of the beers in the strip club unlocked Jan 3rd, 2012 12:13 am | 10 | |
| Downtown Barrel Beatdown Kill 10 aliens with tossed objects unlocked Jan 4th, 2012 12:41 am | 15 | |
| Special Thanks Watch the credits all the way through unlocked Jan 4th, 2012 12:23 am | 5 | |
| Gunslinger Carry the gold pistol through the whole SP campaign unlocked Jan 4th, 2012 12:13 am | 50 | |
| Piece of Cake Complete the SP campaign on Easy Difficulty unlocked Jan 4th, 2012 12:13 am | 20 | |
| Let's Rock Complete the SP campaign on Normal Difficulty | 30 | |
| Beating the One-Eyed Worm Defeat the Energy Leech unlocked Jan 3rd, 2012 11:28 pm | 35 | |
| Octacide Defeat the Octaking unlocked Jan 3rd, 2012 10:14 pm | 25 | |
| Fork the Pork Kill 6 aliens with the forklift unlocked Jan 3rd, 2012 9:29 pm | 10 | |
| I Need a Date Look at every page of a calendar unlocked Jan 3rd, 2012 2:21 am | 5 | |
| Freeze Well! Kill 15 frozen aliens unlocked Jan 3rd, 2012 2:28 am | 20 | |
| Dead Useful Kill 10 aliens with environmental explosives unlocked Jan 3rd, 2012 10:47 pm | 15 | |
| A Good Dam Fight Defeat the Battlelord on the Hoover Dam unlocked Jan 3rd, 2012 2:09 am | 25 | |
| He's Got a Hologram! Use a Holoduke in SP unlocked Jan 3rd, 2012 1:01 am | 5 | |
| Road Rage Kill 15 aliens with the monster truck unlocked Jan 3rd, 2012 1:15 am | 20 | |
| On the Noggin Kill 30 aliens with headshots unlocked Jan 3rd, 2012 1:46 am | 25 | |
| Lots of Whacking Win a game of Alien Abortion in the strip club unlocked Jan 4th, 2012 12:58 am | 25 | |
| Not Bad for a Human Defeat the Alien Queen unlocked Jan 2nd, 2012 11:22 pm | 40 | |
| Noms Eat 10 pieces of food during the SP campaign unlocked Jan 4th, 2012 12:26 am | 10 | |
| Turd Burglar Find and steal a piece of poo unlocked Dec 29th, 2011 4:22 am | 10 | |
| Trapper Kill 10 aliens with Trip Mines unlocked Jan 3rd, 2012 2:02 am | 20 | |
| I Need a Towel Get hit by 10 Pregnator bombs unlocked Jan 3rd, 2012 9:45 pm | 10 | |
| FBT Get knocked down 10 times unlocked Jan 2nd, 2012 11:09 pm | 10 | |
| Hippy-Stomper Foot stomp 12 aliens unlocked Jan 3rd, 2012 12:59 am | 20 | |
| Nuclear Devastation Kill 250 aliens unlocked Jan 2nd, 2012 11:10 pm | 50 | |
| Pit Champion Defeat the Battlelord in Las Vegas unlocked Jan 2nd, 2012 9:36 pm | 25 | |
| Substance Abuser Drink beer while on steroids or vice versa in SP unlocked Jan 2nd, 2012 9:31 pm | 10 | |
| Judge, Jury, Executioner Execute 20 aliens | 20 | |
| Juiced Take steroids in SP unlocked Dec 31st, 2011 2:13 am | 5 | |
| Annihilation Kill 100 aliens unlocked Jan 2nd, 2012 9:26 pm | 40 | |
| Baron von Nukem Shoot down 20 alien fighters unlocked Jan 4th, 2012 12:51 am | 20 | |
| Natural Disaster 3x Kill 3 aliens at once unlocked Jan 2nd, 2012 10:54 pm | 10 | |
| Big Guns, Big Ships Blow up 5 enemy gunships or dropships unlocked Jan 2nd, 2012 10:10 pm | 10 | |
| Extermination Kill 50 aliens unlocked Dec 31st, 2011 2:19 am | 25 | |
| Flagon of Chuckles Drink a beer in SP unlocked Dec 31st, 2011 2:06 am | 5 | |
| Nobody Likes a Whiner Knock out the talent at the talk show unlocked Dec 31st, 2011 1:56 am | 5 | |
| One-Eyed Freak Defeat the Cycloid unlocked Dec 29th, 2011 4:29 am | 10 | |
| Sunday, Black Sunday Shoot down the blimp above the stadium unlocked Dec 29th, 2011 4:27 am | 5 | |
| Drawrings Doodle something on the whiteboard in SP unlocked Dec 29th, 2011 4:23 am | 10 | |
| Duke Angry, Duke Smash! Kill 15 aliens with melee attacks while on steroids unlocked Jan 4th, 2012 12:44 am | 20 | |
| Bucket Head Find all 3 helmets in the SP campaign unlocked Jan 3rd, 2012 11:18 pm | 30 | |
| Companion Barrel Unlock the secret closet at the end of the Forkstop unlocked Jan 3rd, 2012 9:39 pm | 10 | |
| Pescaphobe Kill all the catfish in the underwater level | 10 | |
| Air-Duke Win air hockey with a score of 7-0 in the strip club | 30 | |
| Balls of Steel Earn a 1,000,000 pinball score in SP | 25 |
