| icon | info | score |
|---|---|---|
| Another Piece of Cake Beat The Doctor Who Cloned Me campaign on Easy Difficulty | 20 | |
| Let's Rock Out Beat The Doctor Who Cloned Me campaign on Normal Difficulty | 30 | |
| Bloody Red Rover Kill 30 enemies with the moon rover | 10 | |
| Bubble Buster Kill 10 expanded enemies with melee attacks | 10 | |
| Heart to Heart Finish Doctor Proton | 20 | |
| Threesome Kill 3 enemies within 3 seconds with the Impregnader | 10 | |
| Sticky Bomb Like You! Put a Trip Mine on a live alien unlocked Jul 6th, 2011 2:01 pm | 10 | |
| Party Animal Drink all of the beers in the strip club unlocked Jul 6th, 2011 5:22 pm | 10 | |
| Downtown Barrel Beatdown Kill 10 aliens with tossed objects unlocked Jul 6th, 2011 2:00 pm | 15 | |
| Special Thanks Watch the credits all the way through unlocked Jul 7th, 2011 1:06 am | 5 | |
| Gunslinger Carry the gold pistol through the whole SP campaign unlocked Jul 7th, 2011 12:55 am | 50 | |
| Piece of Cake Complete the SP campaign on Easy Difficulty unlocked Jul 7th, 2011 12:55 am | 20 | |
| Let's Rock Complete the SP campaign on Normal Difficulty unlocked Jul 7th, 2011 12:55 am | 30 | |
| Beating the One-Eyed Worm Defeat the Energy Leech unlocked Jul 7th, 2011 12:21 am | 35 | |
| Octacide Defeat the Octaking unlocked Jul 6th, 2011 10:03 pm | 25 | |
| Fork the Pork Kill 6 aliens with the forklift unlocked Jul 6th, 2011 9:28 pm | 10 | |
| I Need a Date Look at every page of a calendar unlocked Jul 6th, 2011 8:31 pm | 5 | |
| Freeze Well! Kill 15 frozen aliens unlocked Jul 6th, 2011 8:41 pm | 20 | |
| Dead Useful Kill 10 aliens with environmental explosives unlocked Jul 6th, 2011 2:30 pm | 15 | |
| A Good Dam Fight Defeat the Battlelord on the Hoover Dam unlocked Jul 6th, 2011 8:21 pm | 25 | |
| He's Got a Hologram! Use a Holoduke in SP unlocked Jul 6th, 2011 6:23 pm | 5 | |
| Road Rage Kill 15 aliens with the monster truck unlocked Jul 6th, 2011 7:04 pm | 20 | |
| On the Noggin Kill 30 aliens with headshots unlocked Jul 6th, 2011 7:06 pm | 25 | |
| Lots of Whacking Win a game of Alien Abortion in the strip club unlocked Jul 7th, 2011 1:14 am | 25 | |
| Not Bad for a Human Defeat the Alien Queen unlocked Jul 6th, 2011 4:33 pm | 40 | |
| Noms Eat 10 pieces of food during the SP campaign unlocked Jul 5th, 2011 7:02 pm | 10 | |
| Turd Burglar Find and steal a piece of poo unlocked Jul 5th, 2011 6:43 pm | 10 | |
| Trapper Kill 10 aliens with Trip Mines unlocked Jul 6th, 2011 9:16 pm | 20 | |
| I Need a Towel Get hit by 10 Pregnator bombs unlocked Jul 6th, 2011 3:47 pm | 10 | |
| FBT Get knocked down 10 times | 10 | |
| Hippy-Stomper Foot stomp 12 aliens unlocked Jul 6th, 2011 6:24 pm | 20 | |
| Nuclear Devastation Kill 250 aliens unlocked Jul 6th, 2011 3:44 pm | 50 | |
| Pit Champion Defeat the Battlelord in Las Vegas unlocked Jul 6th, 2011 2:23 pm | 25 | |
| Substance Abuser Drink beer while on steroids or vice versa in SP unlocked Jul 6th, 2011 2:47 pm | 10 | |
| Judge, Jury, Executioner Execute 20 aliens unlocked Jul 6th, 2011 8:29 pm | 20 | |
| Juiced Take steroids in SP unlocked Jul 6th, 2011 1:35 pm | 5 | |
| Annihilation Kill 100 aliens unlocked Jul 6th, 2011 2:00 pm | 40 | |
| Baron von Nukem Shoot down 20 alien fighters unlocked Jul 8th, 2011 6:26 pm | 20 | |
| Natural Disaster 3x Kill 3 aliens at once unlocked Jul 6th, 2011 2:15 pm | 10 | |
| Big Guns, Big Ships Blow up 5 enemy gunships or dropships unlocked Jul 6th, 2011 5:40 pm | 10 | |
| Extermination Kill 50 aliens unlocked Jul 6th, 2011 12:54 pm | 25 | |
| Flagon of Chuckles Drink a beer in SP unlocked Jul 5th, 2011 10:15 pm | 5 | |
| Nobody Likes a Whiner Knock out the talent at the talk show unlocked Jul 5th, 2011 7:10 pm | 5 | |
| One-Eyed Freak Defeat the Cycloid unlocked Jul 5th, 2011 6:51 pm | 10 | |
| Sunday, Black Sunday Shoot down the blimp above the stadium unlocked Jul 7th, 2011 1:23 am | 5 | |
| Drawrings Doodle something on the whiteboard in SP unlocked Jul 5th, 2011 6:45 pm | 10 | |
| Duke Angry, Duke Smash! Kill 15 aliens with melee attacks while on steroids unlocked Jul 6th, 2011 9:31 pm | 20 | |
| Bucket Head Find all 3 helmets in the SP campaign unlocked Jul 7th, 2011 12:05 am | 30 | |
| Companion Barrel Unlock the secret closet at the end of the Forkstop unlocked Jul 6th, 2011 9:44 pm | 10 | |
| Pescaphobe Kill all the catfish in the underwater level unlocked Jul 7th, 2011 12:11 am | 10 | |
| Air-Duke Win air hockey with a score of 7-0 in the strip club unlocked Jul 6th, 2011 4:51 pm | 30 | |
| Balls of Steel Earn a 1,000,000 pinball score in SP unlocked Jul 5th, 2011 10:09 pm | 25 |
